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The phosphorylated HER3 supplies docking web-sites for p85 subunit of PI3K. The absolutely activated PI3K complex is produced by binding of p110 subunit of PI3K to p85 which is ready to develop PIP3 by means of phosphorylating the PIP2. AKT binds to PIP3 which is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both equally threonine an